Great Dane vaccination schedule

A general Great Dane puppy vaccination schedule by age, with what each vaccine protects against. Schedules for the US, the UK and the EU. Your vet sets the actual one.

DHPP #1
6 to 8 weeks
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Bordetella (if going to puppy class or daycare)
6 to 8 weeks
Protects against kennel cough (Bordetella).
DHPP #2
10 to 12 weeks
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Leptospirosis #1 (at 12 weeks or older)
10 to 12 weeks
Protects against leptospirosis. Core for all dogs in the US since the 2024 AAHA update; core in other regions where the disease is present (WSAVA 2024).
Lyme #1 (regional)
10 to 12 weeks
Protects against Lyme disease, which matters most in tick-heavy areas.
Rabies #1
12 to 16 weeks, as state or local law sets it
Protects against rabies.
DHPP final dose
16 weeks or later
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Leptospirosis #2 (2 to 4 weeks after the first)
16 weeks or later
Protects against leptospirosis. Core for all dogs in the US since the 2024 AAHA update; core in other regions where the disease is present (WSAVA 2024).
Lyme #2 (2 to 4 weeks after the first)
16 weeks or later
Protects against Lyme disease, which matters most in tick-heavy areas.
DHPP booster
12 to 16 months
Protects against distemper, hepatitis (adenovirus), parainfluenza and parvovirus.
Leptospirosis booster
12 to 16 months
Protects against leptospirosis. Core for all dogs in the US since the 2024 AAHA update; core in other regions where the disease is present (WSAVA 2024).
Rabies booster
12 to 16 months
Protects against rabies.
Lyme yearly
12 to 16 months
Protects against Lyme disease, which matters most in tick-heavy areas.
Bordetella yearly
12 to 16 months
Protects against kennel cough (Bordetella).

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Questions

When should my Great Dane start vaccinations?

Most Great Dane puppies start their first DHPP between 6 and 8 weeks in the US, or 6 to 9 weeks in the UK and EU. Use the form above with your puppy's age and country to see the next-due date.

When can my Great Dane start long walks?

Short walks start after the final puppy vaccination (given at 16 weeks or later), when your vet says protection is in place. Long-distance walks, running, jumping, and stair work wait until your vet confirms growth is finished, at about 18 months.

Should my Great Dane get titer testing later?

Many vets offer it for adult giant breeds. Discuss it after the first-year series is complete.

Are Great Danes more sensitive to vaccines?

Not specifically. Standard DHPP schedule applies. The bigger giant-breed concern is over-exercise, not vaccine reactions.

Same schedule for a Great Dane mix?

Yes. The core vaccines are the same for purebreds and mixes: DHPP, leptospirosis in the US (AAHA), and rabies where the law or travel requires it. Vaccines such as Lyme and Bordetella depend on lifestyle and region, not breed. The schedule above works for any Great Dane mix.